Quinolines and derivatives
Apexbio Technology LLC WAY-600 1062159-35-6 200mg
WAY-600 is an ATP-competitive inhibitor targeting mammalian target of rapamycin (mTOR) specifically inhibiting the phosphorylation activity mediated by mTOR complexes It suppresses mTORC1 signaling via inhibition of phosphorylation of ribosomal S6 kinase (S6K) at Thr389 and attenuates mTORC2 signaling by inhibiting phosphorylation of protein kinase B (AKT) at Ser473 Importantly WAY-600 does not interfere with AKT phosphorylation at Thr308 The compound demonstrates marked selectivity for mTOR over phosphatidylinositol 3-kinase (PI3K) isoforms displaying greater than 100-fold selectivity against PI3K and over 500-fold selectivity against PI3K WAY-600 represents a valuable tool for investigating mTOR-dependent signaling pathways metabolism regulation cellular proliferation autophagy and related oncological and metabolic research areas
Medchemexpress LLC Desonide | 638-94-8 | 99.2% | 200 MG
Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. It can also specifically bind to the mutant huntingtin protein (mHTT), reducing the level and toxicity of mHTT. Desonide can be used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis.
- Non-fluorinated corticosteroid anti-inflammatory agent
- Modulates glucocorticoid receptor activity
- Specifically binds to mutant huntingtin protein (mHTT)
- Reduces mutant huntingtin protein (mHTT) levels and toxicity
- Used in Huntington's disease research
- Used in inflammatory disease research, such as atopic dermatitis
- Inhibits mHTT-induced cytotoxicity
- Reduces apoptotic signals and improves cell survival
- Demonstrates therapeutic effects in Huntington's disease mouse models
- Rescues behavioral deficits and lowers mHTT aggregates
Apexbio Technology LLC YC 1 170632-47-0 200mg
YC-1 (CAS 170632-47-0) is a small molecule originally identified as an inhibitor of hypoxia-inducible factor-1 (HIF-1 ) a transcription factor that regulates genes involved in angiogenesis cell survival and tumor progression under hypoxic conditions YC-1 suppresses the transcriptional activity of HIF-1 with an IC50 of 1 2 M and inhibits HIF-1 expression at the post-transcriptional level in hypoxic hepatocellular carcinoma cell models In vivo YC-1 reduces tumor size and vascularization accompanied by decreased expression of HIF-1 and HIF-1-regulated genes YC-1 serves as a tool for investigating HIF-1 signaling pathways and their roles in cancer biology and hypoxia-associated diseases
Medchemexpress LLC Trimethobenzamide hydrochloride | 554-92-7 | 99.9% | 200 MG
Trimethobenzamide hydrochloride is a non-phenothiazine benzamide antiemetic that acts centrally to block D2 receptors. It inhibits the medullary chemoreceptor trigger zone, blocking emetic impulses to prevent nausea and vomiting.
- Acts as a blocker of the D2 receptor
- Used to prevent nausea and vomiting
- Exhibits 60% to 100% oral bioavailability
- Achieves peak effect approximately 45 minutes after oral administration
- Achieves peak effect approximately 30 minutes after intramuscular administration
Apexbio Technology LLC Temsirolimus 162635-04-3 200mg
Temsirolimus (CCI-779) is an ester analog of rapamycin functioning as an inhibitor of the mammalian target of rapamycin (mTOR) The compound suppresses mTOR signaling pathways thus inhibiting cellular proliferation and growth In preclinical studies on breast cancer cell lines Temsirolimus displayed inhibitory activities with reported IC50 values of 0 6 nM in BT-474 cells 0 7 nM in MDA-MB-468 and SKBR-3 cells and 50 nM in MCF-7 cells It has been examined in xenograft models of tumors with PTEN mutations and multiple myeloma for investigating pathways related to cell-cycle progression and proliferation regulated by mTOR
Medchemexpress LLC Mivavotinib monohydrochloride | 1952251-28-3 | 99.9% | 380.85 g/mol | C17H22ClFN6O | 5 MG
Mivavotinib monohydrochloride is an investigational small-molecule dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), supplied as a white to off-white solid for research use. The monohydrochloride salt displays low-nanomolar inhibitory activity against SYK and FLT3 and is provided with high purity for preclinical studies.
- Dual SYK/FLT3 inhibitor for preclinical research.
- High purity (99.9%).
- White to off-white solid formulation.
- Provided as a monohydrochloride salt for improved stability.
- Low-nanomolar potency against target kinases.
- Store at 4°C and protect from moisture for long-term stability.
TARGETMOL CHEMICALS INC ON-01910 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. purity: 99%
Medchemexpress LLC 2-(pyridyldithio)ethylamine hydrochloride | 106139-15-5 | MFCD01863453 | 99.9% | 222.76 g/mol | C7H11ClN2S2 | 200 MG
2-(Pyridyldithio)ethylamine hydrochloride is a disulfide intercalating cross-linking reagent that combines a 2-pyridyl disulfide moiety with a primary amine, supplied as a hydrochloride salt. It is designed for introducing cleavable disulfide handles in bioconjugation and reversible cross-linking applications, supporting peptide and protein conjugation workflows with high purity and defined storage recommendations.
- Enables formation of reversible disulfide linkages for cleavable conjugates.
- Provides a reactive primary amine for standard coupling chemistries.
- Contains a 2-pyridyl disulfide for efficient thiol-exchange reactions.
- Suitable for peptide and protein conjugation workflows.
- High purity supports reproducible conjugation results.
Apexbio Technology LLC Regorafenib hydrochloride(Synonyms: Regorafenib HCl, BAY 73-4506, Stivarga, BAY73-4506 hydrochloride, Regorafenib hydrochloride salt), 200mg, CAS: 835621-07-3.
Regorafenib hydrochloride (CAS 835621-07-3) is an orally bioavailable small molecule inhibitor targeting multiple protein kinases including c-KIT VEGFR2 and B-Raf It inhibits these kinases with IC50 values of approximately 17 nM (c-KIT) 40 nM (VEGFR2) and 69 nM (B-Raf) By blocking kinase signaling Regorafenib hydrochloride effectively interrupts tumor-associated pathways involved in cell proliferation angiogenesis and survival It is widely used in oncology research for studies focused on kinase-mediated tumor growth and vascularization mechanisms
eMolecules 5-METHOXY-8-QUINOLINOL | 57334-35-7 | MFCD18414704 | 1g
AstaTech | 5-METHOXY-8-QUINOLINOL | 1g | 273172844 | 76306 | 95.000 | 57334-35-7 | MFCD18414704 | 175.187 | C10H9NO2
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Medchemexpress LLC B7-H2/ICOSLG protein, rat recombinant, C-His tagged | >95.0% | 500 UG
Recombinant rat B7-H2 (ICOSLG) protein expressed in HEK293 cells and purified for use in binding and functional assays. Supplied lyophilized with a C-terminal His tag, it is intended for research applications studying ICOS-ICOSLG interactions.
- Recombinant rat ICOS ligand expressed in HEK293 cells.
- C-terminal His tag for detection and purification.
- Supplied lyophilized from PBS, pH 7.4.
- Purity >95.0% by reducing SDS-PAGE.
- Sequence corresponds to residues E25-K261.
- Approximate molecular weight 40-60 kDa.
- Recommended reconstitution ≥100 μg/mL; store lyophilized at -20°C.
- Validated in ELISA with ED50 ≈ 89.92 ng/mL.
![Medchemexpress LLC 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid | 252916-29-3 | MFCD09743433 | >98.0% | 310.3 g/mol | C18H18N2O3 | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243943.png-250.jpg)
Medchemexpress LLC 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid | 252916-29-3 | MFCD09743433 | >98.0% | 310.3 g/mol | C18H18N2O3 | 200 MG
Orantinib is a small-molecule, orally bioavailable receptor tyrosine kinase inhibitor that selectively inhibits VEGFR2, PDGFRβ, and FGFR1, blocking receptor autophosphorylation and angiogenesis. It is used in preclinical and clinical research for tumor growth inhibition and antiangiogenic studies. Chemical formula C18H18N2O3; molecular weight ~310.3 g/mol; CAS 252916-29-3.
- Multi-target inhibition of VEGFR2, PDGFRβ, and FGFR1.
- Orally bioavailable small molecule suitable for in vivo and in vitro studies.
- Blocks receptor autophosphorylation and inhibits angiogenesis.
- Applied in oncology and angiogenesis research applications.
- High purity material appropriate for research use.
Medchemexpress LLC Mivavotinib | 1312691-33-0 | 344.39 g/mol | C17H21FN6O | 50 MG
Mivavotinib is a small-molecule research inhibitor with dual activity against spleen tyrosine kinase (SYK) and FMS-like tyrosine kinase 3 (FLT3). Supplied as a laboratory-grade powder, it is intended for research and analytical use only and is not for human therapeutic applications. The compound is characterized by CAS number 1312691-33-0 and a molecular weight of approximately 344.39 g/mol.
- dual inhibition of SYK and FLT3 for mechanistic studies
- supplied as a stable powder suitable for analytical workflows
- well-characterized by CAS and molecular-weight identifiers
- available in small research-friendly package sizes
- intended for research use with appropriate safety precautions
![Medchemexpress LLC 2-phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide | 113906-27-7 | 99.9% | 320.34 g·mol⁻¹ | C19H16N2O3 | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000213508.png-250.jpg)
Medchemexpress LLC 2-phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide | 113906-27-7 | 99.9% | 320.34 g·mol⁻¹ | C19H16N2O3 | 200 MG
PNU-74654 is a small-molecule inhibitor of the Wnt/β-catenin signaling pathway that disrupts the β-catenin-TCF interaction. It is supplied for research use and is characterized by reported cellular activity (IC50 129.8 μM in NCI-H295 cells), defined physicochemical properties, and high purity suitable for biochemical and cell-based assays.
- Inhibits Wnt/β-catenin signaling by blocking β-catenin-TCF interaction.
- Reported cellular potency: IC50 129.8 μM in NCI-H295 cells.
- High chemical purity for reliable experimental results.
- Well characterized physicochemical properties (MW 320.34, formula C19H16N2O3).
- Suitable for in vitro biochemical and cell-based assays (research use only).
Medchemexpress LLC 3-(N-maleimido-propionylamino)-propyl-sulfonic acid sodium salt | 185332-92-7 | MFCD17215919 | 98.8% | 382.28 g·mol⁻¹ | C12H11N2NaO9S | 25 MG
Sulfo-GMBS is a water-soluble, heterobifunctional cross-linker bearing a sulfo-NHS ester reactive toward primary amines and a maleimide reactive toward sulfhydryl groups. It enables efficient amine-to-thiol conjugation in aqueous buffers for protein and peptide modification, labeling, and cross-linking workflows. The sodium sulfonate improves aqueous solubility for biological applications.
- Water-soluble heterobifunctional cross-linker for amine-to-thiol coupling
- Contains a sulfo-NHS ester reactive toward primary amines
- Contains a maleimide group selective for sulfhydryl groups
- Suitable for conjugation in aqueous buffers and physiological conditions
- High purity supports consistent conjugation performance
- Applicable to protein labeling, cross-linking, and bioconjugation assays